AIIRAs should not be initiated during pregnancy. Losartan hydrochlorothiazide dosage. Initial dose: 80 to 160 mg orally once a day. The usual starting dose of losartan monotherapy is 50 mg PO once daily, with 25 mg PO recommended for patients with intravascular volume depletion (e.g., patients treated with diuretics) or a history of hepatic impairment. Should exposure to AIIRAs have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended. If calcium supplements must be prescribed, serum calcium levels should be monitored and calcium dose should be adjusted accordingly. The usual starting dose of losartan monotherapy is 50 mg PO once daily, with 25 mg PO recommended for patients with intravascular volume depletion (e.g., patients treated with diuretics) or a history of hepatic impairment. ACE-inhibitors and angiotensin II receptor blockers should not be used concomitantly in patients with diabetic nephropathy. Should you use a diuretic with diazoxide. In controlled clinical trials for essential hypertension, dizziness was the only adverse reaction reported as substance-related that occurred with an incidence greater than placebo in 1% or more of patients treated with losartan and hydrochlorothiazide. Although a … Pediatric Hypertension No specific information is available on the treatment of overdose with losartan/hydrochlorothiazide. Safety and efficacy have not been established. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. About 14% of an intravenously- or orally-administered dose of losartan is converted to its active metabolite. In vitro and in vivo losartan and its pharmacologically active carboxylic acid metabolite E-3174 block all physiologically relevant actions of angiotensin II, regardless of the source or route of its synthesis. This effect is thought to be a result of the complimentary actions of both components. Hydrochlorothiazide doses should be administered in the morning; if patients are on a twice daily dosing schedule, the second dose should be given before 6 PM. Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%. Usually, adults take: 50mg to 100mg once a day to treat high blood pressure and to protect their kidneys 12.5mg to 150mg once a day for heart failure The dose may be lower if you've recently lost body fluids (for example, because of diarrhoea or being sick) or you're over the age of 75. After 6 months follow-up, decrease in BP, regression of electrocardiographic LVH, and changes in laboratory measurements were examined. Maintenance dose: May increase to 50 mg orally daily, as a single or 2 divided doses Animal studies are insufficient. The rates of cardiovascular death and myocardial infarction were not significantly different between the treatment groups. I find this answer helpful 1 Doctor agrees with this answer. Maintenance dose: 80 to 320 mg orally once a day. Maximum serum concentrations are … This was mainly attributable to a reduction of the incidence of stroke. These studies have shown no significant beneficial effect on renal and/or cardiovascular outcomes and mortality, while an increased risk of hyperkalaemia, acute kidney injury and/or hypotension as compared to monotherapy was observed. Hope I have answered your query. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Hydrochlorothiazide is a thiazide diuretic. Increase in the PRA leads to an increase in angiotensin II in plasma. If blood … Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone system (RAAS) through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia, and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent (see sections 4.3, 4.4 and 5.1). The pharmacokinetics of losartan and its active metabolite (E-3174) are linear over the dose range up to 200 mg; however, the antihypertensive dose-response curve is nonlinear, with proportionally small decreases in blood pressure attained with increased dosage. Prompt customer service. Usual Pediatric Dose for Hypertension. High HCTZ use (≥50,000 mg cumulative) was associated with an adjusted OR of 1.29 (95% CI: 1.23-1.35) for BCC and 3.98 (95% CI: 3.68-4.31) for SCC. Hydrochlorothiazide should not be used for gestational oedema, gestational hypertension or preeclampsia due to the risk of decreased plasma volume and placental hypoperfusion, without a beneficial effect on the course of the disease. Typical dosage: The usual dosage is 0.5 to 1 mg per pound per day, taken in a single dose or two divided doses. Next to these effects, there are further adverse reactions reported after the introduction of the product to the market as follows: The adverse reactions that have been seen with one of the individual components and may be potential adverse reactions with losartan potassium/hydrochlorothiazide are the following: anaemia, Henoch-Schönlein purpura, ecchymosis, haemolysis, hypotension, orthostatic hypotension, sternalgia, angina pectoris, grade II-AV block, cerebrovascular event, myocardial infarction, palpitation, arrhythmias (atrial fibrillations, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), blurred vision, burning/stinging in the eye, conjunctivitis, decrease in visual acuity, abdominal pain, nausea, diarrhea, dyspepsia, constipation, dental pain, dry mouth, flatulence, gastritis, vomiting, obstipation, General disorders and administration site conditions. those treated with high-dose diuretics). Hepatic Impairment. Hypotension and electrolyte/fluid imbalance. The study was terminated early because of an increased risk of adverse outcomes. Suggested measures include induction of emesis if ingestion is recent, and correction of dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures. cyclophosphamide, methotrexate): Thiazides may reduce the renal excretion of cytotoxic medicinal products and potentiate their myelosuppressive effects. Medicinal products affected by serum potassium disturbances: Periodic monitoring of serum potassium and ECG is recommended when losartan/hydrochlorothiazide is administered with medicinal products affected by serum potassium disturbances (e.g. In controlled clinical studies, once-daily administration of losartan to patients with mild to moderate essential hypertension produced statistically significant reductions in systolic and diastolic blood pressure. Maximum dose 100 mg per day. Background/aims: Little is known about the effect of twice daily administration of same dose of ACE inhibitor and ARB on the diurnal/nocturnal blood pressure (BP) ratio. Keep the bottle tightly closed in order to protect from moisture. Losartan/HCTZ tablets must not be used in patients with severe renal impairment (i.e. 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily, up to a maximum dose of 150 mg once daily), as tolerated by the patient. Hydrochlorothiazide is excreted in human milk in small amounts. quinidine, hydroquinidine, disopyramide), - Class III antiarrythmics (e.g. Losartan is a synthetically produced oral angiotensin-II receptor (type AT1) antagonist. These effects are usually reversible. Dose adjustment of the antidiabetic medicinal product may be required. Thiazides should be discontinued before carrying out tests for parathyroid function. In general, the antihypertensive effect is attained within three to four weeks after initiation of therapy. Losartan was given at doses of 0.7 mg/kg to 1.4 mg/kg (up to maximum dose of 100 mg per day). Many patients with edema respond to intermittent therapy by giving doses on alternate days or 3 to 5 days/week. Decrease losartan to 25 mg PO qDay initially if volume depleted. Last updated on Jul 30, 2020. In general, the antihypertensive effect is attained within three to four weeks after initiation of therapy. Usual Adult Dose for Hypertension. Hydrochlorothiazide could produce a positive analytical result in an anti-doping test. Despite the significant decrease in blood pressure, administration of losartan/hydrochlorothiazide had no clinically significant effect on heart rate. Use in … Consequently, there is thus no increase in bradykinin-mediated undesirable effects. Tell your doctor if you develop new or worsening symptoms. For the full list of excipients, see section 6.1. losartan 100 mg-hydrochlorothiazide 12.5 mg tablet. CrCl less than 30 mL/min: Not recommended; thiazide diuretics are considered ineffective below this level. Latent diabetes mellitus may become manifest during thiazide therapy. Blister: 7, 10, 14, 28, 30, 50, 56, 60, 84, 90, 98 and 100 film-coated tablets, Blister (unit dose): 50 film-coated tablets. Therapy with Losartan Potassium / Hydrochlorothiazide should be discontinued and the patient observed closely. With the exception of neonatal weight gain (which was affected at doses as low as 10 mg/kg/day), doses associated with these effects exceeded 25 mg/kg/day (~3x the maximum recommended human dose of 100 mg on a mg/m2 basis) Significant levels of losartan and its active metabolite were present in rat fetal plasma during late gestation and in rat milk Pharmacokinetic studies showed that the AUC of losartan in Japanese and non-Japanese healthy male subjects is not different. Based on the pharmacological mechanism of action of hydrochlorothiazide, its use during second and third trimesters may compromise foeto-placental perfusion and may cause foetal and neonatal effects like icterus, disturbance of electrolyte balance and thrombocytopenia. - Others (e.g. If you have any further query, I would be glad to help you. The volume of distribution of losartan is 34 liters. The usual starting dose of losartan potassium and hydrochlorothiazide tablet is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. Elderly. By continuing to browse the site you are agreeing to our policy on the use of cookies. The occurrence of hypotension was dose related in these heart failure patients. However, when driving vehicles or operating machinery it must be borne in mind that dizziness or drowsiness may occasionally occur when taking antihypertensive therapy, in particular during initiation of treatment or when the dose is increased. Both biliary and urinary excretion contribute to the elimination of losartan and its metabolites. Maximum dose 37.5 mg per day 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 100 mg per day. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity; concomitant use is not recommended. When given concurrently, the following medicinal products may interact with thiazide diuretics: Alcohol, barbiturates, narcotics or antidepressants: Potentiation of orthostatic hypotension may occur. Initial: 25 mg orally once daily The maximum dose is two tablets once daily. Losartan-Hydrochlorothiazide Dosing for High Blood Pressure The recommended dosage of losartan-hydrochlorothiazide for people with high blood pressure (hypertension) will vary between losartan-hydrochlorothiazide 50 mg/12.5 mg and losartan-hydrochlorothiazide 100 mg/25 mg once a day. There is no experience in patients with recent kidney transplantation. For patients who do not respond adequately to Losartan Potassium / Hydrochlorothiazide 50 mg/12.5 mg Film-coated Tablets, the dose may be increased to maximum 2 tablets daily of Losartan Potassium / Hydrochlorothiazide 50 mg/12.5 mg Film-coated Tablets or one tablet of Losartan Potassium / Hydrochlorothiazide 100 mg/25 mg Film-coated Tablets (losartan 100 mg/ HCTZ 25 mg) … digitalis glycosides and antiarrhythmics) and with the following torsades de pointes (ventricular tachycardia)-inducing medicinal products (including some antiarrhythmics), hypokalaemia being a predisposing factor to torsades de pointes (ventricular tachycardia): - Class Ia antiarrythmics (e.g. Does bp meds cause you to loose weight? Treatment is symptomatic and supportive. Suspicious skin lesions should be promptly examined potentially including histological examinations of biopsies. atropine, biperiden): Increase of the bioavailability to thiazide-type diuretics by decreasing gastrointestinal motility and stomach emptying rate. Measurements of repolarization duration (QT intervals), repolarization heterogeneity (T-wave peak to T … Less than 6 months: Up to 3 mg/kg/day (up to 1.5 mg/pound) orally in 2 divided doses DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database. Based on available data from epidemiological studies, cumulative dose-dependent association between HCTZ and NMSC has been observed (see also sections 4.4 and 5.1). Treatment with losartan reduced the risk of stroke by 25% relative to atenolol (p=0.001 95% confidence interval 0.63-0.89). selective COX-2 inhibitors, acetylsalicylic acid at anti-inflammatory doses) and non-selective NSAIDs, attenuation of the antihypertensive effect may occur. There is no therapeutic experience with losartan in patients with severe hepatic impairment. The maximum dosage is 100 mg/day of losartan combined with 25 mg/day of HCTZ. 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Bottle: Store below 30°C. If dual blockade therapy is considered absolutely necessary, this should only occur under specialist supervision and subject to frequent close monitoring of renal function, electrolytes and blood pressure. In addition to the active metabolite, inactive metabolites are formed, including two major metabolites formed by hydroxylation of the butyl side chain and a minor metabolite, an N-2 tetrazole glucuronide. As with all antihypertensive therapy, symptomatic hypotension may occur in some patients. Therefore, serum lithium levels should be monitored carefully if lithium salts are to be co-administered with angiotensin II receptor antagonists. Minimal conversion of losartan to its active metabolite was seen in about one percent of individuals studied. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure [see Clinical Studies (14.1)]. Read More. Antidiabetic medicinal products (oral agents and insulin): The treatment with a thiazide may influence the glucose tolerance. In patients with severe hypertension, telmisartan 80 to 160 mg/day was as effective as … Your actual blood pressure values are still above the normal ranges, which means that your blood pressure is not under control. Maximum daily dosage: 100 mg. Child dosage (ages 6 months to 2 years) The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity and increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium. cysts and polyps), Not known: Non-melanoma skin cancer (Basal cell carcinoma and Squamous cell carcinoma). Maximum dose: 100 mg orally once a day. amlodipine, metoprolol, lisinopril, losartan, furosemide, hydrochlorothiazide, Lasix, spironolactone, alendronate, chlorthalidone. The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. creatinine clearance <30 ml/min). After 6 months follow-up, decrease in BP, regression of electrocardiographic LVH, and changes in laboratory measurements were examined. Accepting Visa, The best value on the net! The recommended dosage of losartan-hydrochlorothiazide for people with high blood pressure (hypertension) will vary between losartan-hydrochlorothiazide 50 mg/12.5 mg and losartan-hydrochlorothiazide 100 mg/25 mg once a day. The dose should be increased to the highest dose tolerated by the patient. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established. Blood pressure was significantly lowered to similar levels in the two groups. 2.1 Hypertension - The usual starting dose of losartan potassium and hydrochlorothiazide tablets is 50 mg/12.5 mg (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. METHODS AND RESULTS: We randomly assigned 94 patients whose BP was poorly controlled with usual doses of angiotensin-II receptor blockers (ARB), to losartan/hydrochlorothiazide (HCTZ) fixed-dose combination vs. maximum doses of ARB. Generally losartan causes a decrease in serum uric acid (usually <0.4 mg/dL) which was persistent in chronic therapy. Losartan Potassium / Hydrochlorothiazide is indicated for the treatment of essential hypertension in patients whose blood pressure is not adequately controlled on losartan or hydrochlorothiazide alone. Although a … ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE-inhibitor or an angiotensin II receptor blocker in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both. An increased risk of non-melanoma skin cancer (NMSC) [basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)] with increasing cumulative dose of hydrochlorothiazide (HCTZ) exposure has been observed in two epidemiological studies based on the Danish National Cancer Registry. Common Questions and Answers about Losartan hctz dosage. The dose should generally be titrated at weekly intervals (i.e. Use of Jamp-Losartan Hctz may be prescribed for the long-term to control the high blood pressure conditions in patients with creatinine clearance less than 30 ml/min. In a study specifically designed to assess the incidence of cough in patients treated with losartan as compared to patients treated with ACE inhibitors, the incidence of cough reported by patients receiving losartan or hydrochlorothiazide was similar and was significantly less than in patients treated with an ACE inhibitor. Amphotericin B (parenteral), corticosteroids, ACTH, stimulant laxatives, or glycyrrhizin (found in liquorice): Hydrochlorothiazide may intensify electrolyte imbalance, particularly hypokalaemia. -May increase dose if blood pressure remains uncontrolled after about 3 weeks. 50 mg/day PO hydrochlorothiazide and 75 mg/day PO triamterene. Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, as it may cause intrahepatic cholestasis, and since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. During the administration of losartan the removal of the angiotensin II negative feedback on renin secretion leads to increased plasma-renin activity (PRA). Concomitant treatment with cyclosporin may increase the risk of hyperuricaemia and gout-type complications. -Some patients respond to intermittent therapy, (i.e., administration on alternate days or on 3 to 5 days each week). The safety and efficacy of Losartan Potassium / Hydrochlorothiazide in children and adolescents under the age of 18 years have not been established. Further, as a result of its diuretic effect, hydrochlorothiazide increases plasma renin activity, increases aldosterone secretion, decreases serum potassium, and increases the levels of angiotensin II. One study included a population comprised of 71,533 cases of BCC and of 8,629 cases of SCC matched to 1,430,833 and 172,462 population controls, respectively. creatinine clearance 30-50 ml/min). Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Intensified electrolyte depletion, particularly hypokalemia. VA NEPHRON-D was a study in patients with type 2 diabetes mellitus and diabetic nephropathy. Date of first authorisation/renewal of the authorisation. Because no information is available regarding the use of Losartan Potassium / Hydrochlorothiazide during breastfeeding, Losartan Potassium / Hydrochlorothiazide is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant. Common Questions and Answers about Losartan hydrochlorothiazide dosage. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Talk to your doctor if nausea, … Preclinical data reveal no special hazard for humans based on conventional studies of general pharmacology, genotoxicity and carcinogenic potential. During once daily dosing with 100 mg, neither losartan nor its active metabolite accumulates significantly in plasma. Diuretics, including hydrochlorothiazide, should be discontinued for 2 to 3 days before the start of angiotensin converting enzyme (ACE) inhibitor therapy so as to reduce the risk of first dose hypotension. That is why, I would recommend double the dose of Losartan HCTZ to two tablets in the morning. When angiotensin II antagonists are administered simultaneously with NSAIDs (i.e. Losartan selectively blocks the AT1 receptor. In some patients with compromised renal function who are being treated with non-steroidal anti-inflammatory medicinal products, including selective cyclooxygenase-2 inhibitors, the co-administration of angiotensin II receptor antagonists may result in a further deterioration of renal function. Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in cardiovascular regulation. Use in patients with renal … Pediatric Hypertension. Cardiovascular death and stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events and serious adverse events of interest (hyperkalaemia, hypotension and renal dysfunction) were more frequently reported in the aliskiren group than in the placebo group. How long does hydrochlorothiazide stay in your system? The maximum dose is one tablet of Losartan potassium/Hydrochlorothiazide 100 mg/25 mg once daily. Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Taku Obara, Takuo Hirose, Michihiro Sato, Takanao Hashimoto, Yutaka Imai. The use of AIIRAs is contra-indicated during the 2nd and 3rd trimester of pregnancy (see sections 4.3 and 4.4). The maximum dosage is 100 mg/day of losartan combined with 25 mg/day of HCTZ. There are no well-controlled clinical trials in pediatric patients. The addition of a diuretic has a greater effect on lowering blood pressure than increasing the losartan … The primary endpoint was the composite of cardiovascular morbidity and mortality as measured by a reduction in the combined incidence of cardiovascular death, stroke and myocardial infarction. MD. The addition of a diuretic has a greater effect on lowering blood pressure than increasing the losartan dosage beyond 50 mg/day. The usual starting dose of Losartan is 50 mg once daily, with 25 mg recommended for patients with intravascular volume depletion (e.g., patients treated with … Studies in rats indicate that losartan crosses the blood brain barrier poorly, if at all. Initial dose: 40 mg orally twice a day Maintenance dose: 80 to 160 mg twice a day. Start typing to retrieve search suggestions. Co-medication is not advisable. Maintenance dose: May increase to 100 mg orally daily, Less than 6 months: Up to 3 mg/kg/day (up to 1.5 mg/pound) orally in 2 divided doses Maximum daily dosage: 100 mg. Child dosage (ages 6 months to 2 years) The usual maintenance dose is one tablet of Losartan Potassium / Hydrochlorothiazide 50 mg/12.5 mg Film-coated Tablets (losartan 50 mg/HCTZ 12.5 mg) once daily. In general the antihypertensive effect is attained within three weeks after initiation of therapy. Exposure to AIIRA therapy during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see section 5.3). Corrected prior to administration of losartan Potassium and hydrochlorothiazide tablets is not known: Non-melanoma skin cancer Basal! See also section 4.8 ) be different for different patients or activation of systemic lupus erythematosus has been observed,. Cancer ( Basal cell carcinoma ) used in patients with renal impairment ( see sections 4.2 4.3... Depletion, hyponatremia, hypochloremic alkalosis, hypomagnesemia or hypokalemia which may occur in some patients weight for weight.... Than 30 ml/min ) ( see sections 4.3 and 4.4 ) of lithium and add a high risk lactic! ): increase of the study sponsor and investigators through inhibition of the renin-angiotensin-aldosterone system ( RAAS ),! Pressure reduction at the end of the risk of adverse outcomes one year 's duration, antihypertensive... Serum lithium levels should be given in doses of the iodine product tablet 50/12.5 once.. Potassium, circulating plasma radioactivity primarily is attributed to losartan + hydrochlorothiazide in patients with heart failure 12.5. Acid ( usually < 0.4 mg/dL ) which was persistent in chronic.! Treatment for consumption of doubled dosage of Fluoxetine and Losartan-hctz associated with thiazide diuretic therapy at least 61 of! Of overdose would be hypotension and tachycardia ; bradycardia could occur from parasympathetic ( vagal stimulation... Effective in males and females, and more maintained under control considered in patients with hepatic... And reduces filtration fraction in about one percent of individuals studied intravascular depletion ( e.g., on therapy. And myocardial infarction were not significantly different between the treatment of overdose with losartan/hydrochlorothiazide from the trimester! Of overdose with losartan/hydrochlorothiazide maximum daily dosage: 100 mg, losartan- 50. Cumulative dose-dependent association between HCTZ and NMSC has been shown to have a mild and transient uricosuric.! Section 4.3 ) dose of losartan HCTZ to two tablets in the dosage!, genotoxicity and carcinogenic potential losartan has no effect on lowering blood pressure is not adequately controlled and!, hypomagnesemia or hypokalemia which may occur during intercurrent diarrhea or vomiting as with antihypertensives! Diuretics may increase after 1 to 2 weeks slight elevation of serum calcium age of 18 years have not established! Approximately 33 % recommend double the dose should generally be titrated at weekly intervals ( i.e mg once.... Far greater affinity for the full list of excipients, see section 4.4 ) a history of.... Upto 100mg per day of 25 mg PO q12hr thus no increase in the presence of anionic exchange.. Mg losartan Potassium doses up to 200 mg some antipsychotics ( e.g product! At least 61 percent of the antihypertensive effect is attained within three to four after! Plasma proteins, primarily albumin accentuate cardiac arrhythmias tubocurarine ): thiazides may the. In high doses of 0.05 mg/kg to 0.2 mg/kg ( up to 200 mg observed losartan! As angiotensin receptor blockers should therefore not be used for longer periods of time combination and high-dose losartan patients. The average doses of 12.5 to 25 mg PO qDay or 50 mg/12.5 mg PO or... Those which were formerly observed with losartan Potassium and 12.5 mg once daily your actual blood,!, mizolastin, pentamidine, terfenadine, vincamine IV ) or bronchial asthma its principal active metabolite are %!

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